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Peptide YY
Peptide YY (PYY) also known as peptide tyrosine tyrosine or pancreatic peptide YY3-36 is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; but when injected directly into the central nervous system, PYY is anorexigenic, i.e., it decreases appetite. 〔Woods, S. C., & D'Alessio, D. A. (2008). Central control of body weight and appetite. J Clin Endocrinol Metab, 93(11 Suppl 1), S37-50. doi: 10.1210/jc.2008-1630 〕 Peptide YY can be produced as the result of enzymatic breakdown of crude fish proteins and ingested as a food product.〔http://www.bio.umass.edu/biology/mccormick/pdf/Murashita%20et%20al%202009.pdf〕 ==Structure== Peptide YY is related to the pancreatic peptide family by having 18 of its 36 amino acids located in the same positions as pancreatic peptide. The two major forms of peptide YY are PYY1-36 and PYY3-36, which have PP fold structural motifs. However, the most common form of circulating PYY immunoreactivity is PYY3-36, which binds to the Y2 receptor (Y2R) of the Y family of receptors. Peptide YY3-36 (PYY) is a linear polypeptide consisting of 36 amino acids with structural homology to NPY and pancreatic polypeptide.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Peptide YY」の詳細全文を読む
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